Job Description

Job Description:

• We are seeking a talented and self-motivated individual with a B.S. in biology, biochemistry or applicable sciences +5 years of academic/industry experience or Master ‘s Degree and 3+ years of academic/industry experience in biochemistry, who is interested in joining the Protein Production and Quality Attributes team within Discovery Biotherapeutics in San Diego.
• The successful candidate will have knowledge in purification and characterization of bispecific antibodies and will be familiar with state-of-the-art methods to support biotherapeutic discovery efforts.
• The candidate will have demonstrated success in purification of antibodies and complex molecules, executing challenging multi-step purification, analytical data interpretation, troubleshooting and formulation of final product. Experience in automation of high-throughput purification is a plus.
• The candidate will show an independent ability to design purification methods, understand biochemical concepts and interpret data to generate and improve design. Candidates should have excellent communication skills and a collaborative style. Candidate will be expected to participate in team meetings and provide expertise to support discovery programs.

Core job functions:

• Primary responsibility is to perform original research to develop marketable products.
• Special emphasis will be placed on automated antibody and bispecific purification, which will involve working with Client AKTA (Pure/Avant) and Unicorn software. Knowledge of Protein Maker instrument a plus.
• Generate mg to gram quantities of material for in-vivo efficacy studies.
• Develop and optimize high-throughput purification capabilities using Lynx900 and KingFisher Flex System.
• Packing of chromatography columns, operating endotoxin free chromatography, including operating preparative (FPLC) and analytical (HPLC) chromatography systems.
• Analytical characterization including endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (HIC, SEC), capillary electrophoresis (CE-SDS and cIEF), DLS, and mass photometry.
• Buffer preparation, molar concentration quantitation and pH adjustment.
• Storing, inventorying, and ordering department supplies.
• Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.
• Maintain a neat and clean work environment.
• Manage your workload with minimal supervision.
• Collaborate and communicate with cross-functional teams.

Basic qualifications:

• Bachelor's Degree 5+ years of academic / industry experience
• Master's Degree 3+ years of academic / industry experience

Preferred qualifications:

• Bachelor's Degree 5+ years or master’s degree 3+ years with no experience in Biochemistry, Molecular Biology, Bioengineering, Cell biology or related discipline.
• Experience in antibody/bi-specific purification and characterization including, but not limited to SDS-PAGE, CE-SDS, CiEF, AnSEC, endotoxin measurement, A280.
• Automated liquid handling a plus.
• Sample inventory management.
• Exceptional organizational skills and attention to detail.
• Excellent time management skills and multi-tasking capabilities.
• Must be very detail-oriented and organized, with excellent time management and multitasking skills.
• Have outstanding analytic and problem-solving abilities.
• Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure.
• Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team.
• Demonstrate a track record of initiative, creativity, organization, and independent performance at a high level combined with attention to detail and adherence to timelines/deliverables, and documentation.

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