Job Description

About the company

Cahira Technologies Inc is an MIT spinoff company ( We have built the multiple award-winning technology of the world's first autonomous and non-surgical neural implants: novel sub-cellular sized wireless electronic devices that seamlessly integrate with the neurons or other biological cells, enabling brain-computer symbiosis beyond conventional brain-computer interfaces. Join us in our exciting journey to define the future of neurotech!

About the role

We are building a bioengineering group to demonstrate the application of our injectable, wireless nano-implants to restore eyesight without surgery. This includes demonstrations of electrical neuromodulation using these devices in retinal explants and characterizations through multi-electrode array (MEA)/patch-clamp electrophysiology followed by in vivo tests in rodent models for efficacy (brain electrophysiology and behavior) and safety. This team will be responsible for end-to-end execution of all pre-clinical experiments required to bring our retinal prosthesis to IDE-enabling stage.

Qualifications

Required:

1. PhD in neuroscience, vision science, neuro-engineering, biology, bioengineering, biomedical engineering or relevant field
2. Hands-on experience with small-animal ophthalmology and retinal prosthesis for electrical stimulation such as bionic eye, photovoltaic implant, wired implant, sub-retinal or epi-retinal implant, injectable neuro-prosthesis, nanoparticles etc.
3. Hands-on experience with rodent models such as Retinitis Pigmentosa (RP), Age-related Macular Degeneration (AMD) (rd1, rd10, RCS, S334ter etc)
4. Hands-on experience with rodent (mouse/rats) ocular surgery such as retina isolation and injections such as intravitreal/suprachoroidal/sub-retinal/ subtenon injections
5. Hands-on experience with retinal electrophysiology (multi-electrode array (MEA) or patch clamping) ex vivo in isolated retina
6. Hands-on experience with in vivo electrophysiology such as measuring visual evoked potential in brain and electroretinogram (ERG)
7. Hands-on experience with characterizing acuity and resolution through methods such as pattern visual-evoked-potential (VEP) grating-acuity assay, optokinetic/optomotor reflex (OKR) test
8. Hands-on experience with behavioral vision assays and tests such as pupillary light reflex, light/dark box, water-maze tests
9. Hands-on experience in preparing retinal flat-mounts & cryo-sections; performing histology, immunostaining and confocal microscopy.
   
   

Preferred Experience:

1. Experience with data analysis, statistical modeling and programming skills such as MATLAB/Python/COMSOL
2. Experience in building optical equipment
3. Experience in operating fundus camera & optical coherence tomography (OCT)
4. Experience with optogenetics
   
   

Important: Please include a separate section titled "Skills" in your CV, clearly listing your in vivo, in vitro, and other relevant scientific/technical competencies and provide a full list of publications.

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